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Literature summary for 1.14.14.154 extracted from

  • Aoyama, Y.; Funae, Y.; Noshiro, M.; Horiuchi, T.; Yoshida, Y.
    Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P45014DM) in the rat liver (1994), Biochem. Biophys. Res. Commun., 201, 1320-1326.
    View publication on PubMed
Search for more literature for 1.14.14.154

Cloned(Commentary)

Cloned (Comment) Organism
pRT-9 cDNA Rattus norvegicus
pRT-9 clone, pRT-9 protein is P45014DM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme of sterol biosynthetic pathway ?
-
 ?
additional information Saccharomyces cerevisiae enzyme of sterol biosynthetic pathway ?
-
 ?
additional information Embryophyta enzyme of sterol biosynthetic pathway ?
-
 ?
additional information Candida albicans enzyme of sterol biosynthetic pathway ?
-
 ?
additional information Candida tropicalis enzyme of sterol biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida tropicalis
-
-
-
Embryophyta
-
 higher plants
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus
additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Rattus norvegicus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 lanosta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Rattus norvegicus 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Saccharomyces cerevisiae 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida albicans 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol Candida tropicalis 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information enzyme of sterol biosynthetic pathway Rattus norvegicus ?
-
 ?
additional information enzyme of sterol biosynthetic pathway Saccharomyces cerevisiae ?
-
 ?
additional information enzyme of sterol biosynthetic pathway Embryophyta ?
-
 ?
additional information enzyme of sterol biosynthetic pathway Candida albicans ?
-
 ?
additional information enzyme of sterol biosynthetic pathway Candida tropicalis ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Rattus norvegicus
cytochrome P450
-
 Saccharomyces cerevisiae
cytochrome P450
-
 Embryophyta
cytochrome P450
-
 Candida albicans
cytochrome P450
-
 Candida tropicalis
heme heme-thiolate enzyme Rattus norvegicus
heme heme-thiolate enzyme Saccharomyces cerevisiae
heme heme-thiolate enzyme Embryophyta
heme heme-thiolate enzyme Candida albicans
heme heme-thiolate enzyme Candida tropicalis