Literature summary for 1.14.14.14 extracted from

Martin, L.L.; Holien, J.K.; Mizrachi, D.; Corbin, C.J.; Conley, A.J.; Parker, M.W.; Rodgers, R.J.
Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency (2015), J. Steroid Biochem. Mol. Biol., 154, 294-301 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens
expression in Escherichia coli	Sus scrofa

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular dynamics simulations of the dimeric interfaces, i.e.residues 45-496	Homo sapiens
molecular modeling of structure	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11511	-	-
Sus scrofa	P79304	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins	-	Homo sapiens	estrone + formate + 4 H2O + 3 oxidized flavoproteins	-	?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins	-	Sus scrofa	estrone + formate + 4 H2O + 3 oxidized flavoproteins	-	?

Subunits

Subunits	Comment	Organism
homodimer	FRET and crtystallization data	Homo sapiens
homodimer	FRET and crystallization data	Sus scrofa

Synonyms

Synonyms	Comment	Organism
Cyp19A3	-	Sus scrofa
cytochrome P450 aromatase	-	Homo sapiens
P450arom	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	dimerization of the human P450arom, primarily via salt bridges at the I-H loop, leads to greater activity and reduced release of intermediates compared to porcine aromatase	Homo sapiens
physiological function	dimerization of the human P450arom, primarily via salt bridges at the IH loop, leads to greater activity and reduced release of intermediates compared to porcine aromatase.The porcine gonadal P450arom has no ionic interaction at the I-H loop but forms a new intra-molecular salt bridge at the N termini of the I-helix that leads to locking of the substrate	Sus scrofa

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Release 2023.1 (January 2023)