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Literature summary for 1.14.14.14 extracted from

  • Monteiro, R.; Becker, H.; Azevedo, I.; Calhau, C.
    Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity (2006), J. Agric. Food Chem., 54, 2938-2943.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
8-prenylnaringenin flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens
isoxanthohumol flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens
additional information lager beer, alcohol-free beer, stout beer, and xanthohumol-rich stout beer significantly decrease aromatase activity Homo sapiens
xanthohumol flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens ATCC HTB-144
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JAR cell trophoblastic tumor cell of placenta Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000065
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 8-prenylnaringenin
0.0203
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens xanthohumol
0.081
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens isoxanthohumol