Literature summary for 1.14.14.139 extracted from

Sanyal, S.; Bavner, A.; Haroniti, A.; Nilsson, L.M.; Lundasen, T.; Rehnmark, S.; Witt, M.R.; Einarsson, C.; Talianidis, I.; Gustafsson, J.A.; Treuter, E.
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis (2007), Proc. Natl. Acad. Sci. USA, 104, 15665-15670.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis, transcription factor G protein pathway suppressor 2, GPS2, affects CYP8B1 expression, mediated by direct interactions with LRH-1 and HNF4alpha, while the small heterodimer partner, SHP, does not affect the expression, Identification of a functional FXR response element in the human CYP8B1 promoter, regulation mechanism, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2	Homo sapiens	activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview	5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2	activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview	Homo sapiens	5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP8B1	-	Homo sapiens
sterol 12alpha hydroxylase	-	Homo sapiens

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Release 2023.1 (January 2023)