Cloned (Comment) | Organism |
---|---|
expression analysis in healthy livers and liver with primary biliary cirrhosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | Homo sapiens | the enzyme expression is not affected by primary biliary cirrhosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | the enzyme expression is not affected by primary biliary cirrhosis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in bile acid synthesis, repression of bile acid synthesis and induction of basolateral bile acid export may represent adaptive mechanisms to limit bile acid burden in chronic cholestasis, but the changes do not sufficiently counteract cholestatic liver damage, overview | Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | the enzyme expression is not affected by primary biliary cirrhosis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP8B1 | - |
Homo sapiens |