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Literature summary for 1.14.14.139 extracted from

  • Lundell, K.; Wikvall, K.
    Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis (2008), Curr. Drug Metab., 9, 323-331.
    View publication on PubMed
Search for more literature for 1.14.14.139

Cloned(Commentary)

Cloned (Comment) Organism
genetic structure and phylogenetic analysis Mus musculus
genetic structure and phylogenetic analysis Homo sapiens
genetic structure and phylogenetic analysis Rattus norvegicus
genetic structure and phylogenetic analysis Sus scrofa
genetic structure and phylogenetic analysis Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme Mus musculus
Fe2+ a cytochrome P450 enzyme Homo sapiens
Fe2+ a cytochrome P450 enzyme Rattus norvegicus
Fe2+ a cytochrome P450 enzyme Sus scrofa
Fe2+ a cytochrome P450 enzyme Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Sus scrofa
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Oryctolagus cuniculus
-
 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information Mus musculus the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview ?
-
 ?
additional information Homo sapiens the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview ?
-
 ?
additional information Rattus norvegicus the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview ?
-
 ?
additional information Sus scrofa the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview ?
-
 ?
additional information Oryctolagus cuniculus the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Sus scrofa 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Oryctolagus cuniculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview Mus musculus ?
-
 ?
additional information the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview Homo sapiens ?
-
 ?
additional information the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview Rattus norvegicus ?
-
 ?
additional information the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview Sus scrofa ?
-
 ?
additional information the enzyme is involved in trihydroxy bile acid metabolism and cholic acid synthesis from cholesterol, overview Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP8B1
-
 Mus musculus
CYP8B1
-
 Homo sapiens
CYP8B1
-
 Rattus norvegicus
CYP8B1
-
 Sus scrofa
CYP8B1
-
 Oryctolagus cuniculus
More the enzyme belongs to the CYP8B subfamily Mus musculus
More the enzyme belongs to the CYP8B subfamily Homo sapiens
More the enzyme belongs to the CYP8B subfamily Rattus norvegicus
More the enzyme belongs to the CYP8B subfamily Sus scrofa
More the enzyme belongs to the CYP8B subfamily Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
cytochrome a cytochrome P450 enzyme Rattus norvegicus
cytochrome a cytochrome P450 enzyme Oryctolagus cuniculus
cytochrome P450 a cytochrome P450 enzyme Mus musculus
cytochrome P450 a cytochrome P450 enzyme Homo sapiens
cytochrome P450 a cytochrome P450 enzyme Sus scrofa