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Literature summary for 1.14.14.139 extracted from

  • Ellis, E.C.
    Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes (2006), World J. Gastroenterol., 12, 4640-4645.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.139

Inhibitors

Inhibitors Comment Organism Structure
additional information thyroid hormone triiodothyronine, i.e. T3, supresses enzyme expression in vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview Homo sapiens 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?