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Literature summary for 1.14.14.139 extracted from

  • Chen, W.; Suruga, K.; Nishimura, N.; Gouda, T.; Lam, V.N.; Yokogoshi, H.
    Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats (2005), Life Sci., 77, 746-757.
    View publication on PubMed
Search for more literature for 1.14.14.139

Activating Compound

Activating Compound Comment Organism Structure
additional information feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 Rattus norvegicus
additional information feeding of taurine alone has no effect on enzyme expression Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information feeding of cholic acid suppresses expression of CYP8B1, the effect is partly reversed by taurine, feeding of taurine alone has no effect on enzyme expression Mus musculus
additional information feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 10-weeks-old male C75BL/6 mice
-
Rattus norvegicus
-
 5-weeks-old male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP8B1
-
 Mus musculus
CYP8B1
-
 Rattus norvegicus
sterol 12alpha-hydroxylase
-
 Mus musculus
sterol 12alpha-hydroxylase
-
 Rattus norvegicus