Literature summary for 1.14.14.139 extracted from

Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse (2007), Histochem. Cell Biol., 127, 253-261.

Search for more literature for 1.14.14.139

Cloned(Commentary)

Cloned (Comment)	Organism
gene CYP8B1, expression analysis in liver tissues of wild-type, regulation of gene expression, overview	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of CYP8B1 null mice which show increased expression of cholesterol 7alpha-hydroxylase, CYP7A1, EC 1.14.13.17	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cholate supresses enzyme expression	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Mus musculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	Mus musculus	the enzyme is necessary for the synthesis of cholic acid	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	enzyme expression pattern within the liver architecture, zonal distribution pattern, overview	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	-	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2	the enzyme is necessary for the synthesis of cholic acid	Mus musculus	12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP8B1	-	Mus musculus
sterol 12alpha-hydroxylase	-	Mus musculus

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Release 2023.1 (January 2023)