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Literature summary for 1.14.14.139 extracted from

  • Yang, Y.; Zhang, M.; Eggertsen, G.; Chiang, J.Y.
    On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha (2002), Biochim. Biophys. Acta, 1583, 63-73.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
12alpha-hydroxylase gene
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Rattus norvegicus
CYP8B1
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Rattus norvegicus