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Literature summary for 1.14.14.139 extracted from
- Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene (2005), Am. J. Physiol., 288, G685-695.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | IL-1beta inhibits CYP8B1 gene transcription via a mitogen-activated protein kinase/c-Jun NH2-terminal kinase pathway that inhibits HNF4alpha gene expression and its DNA-binding ability. This mechanism may play an important role in the adaptive response to inflammatory cytokines and the protection of the liver during cholestasis | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | IL-1beta inhibits CYP8B1 gene transcription via a mitogen-activated protein kinase/c-Jun NH2-terminal kinase pathway that inhibits HNF4alpha gene expression and its DNA-binding ability. This mechanism may play an important role in the adaptive response to inflammatory cytokines and the protection of the liver during cholestasis | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP8B1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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