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Literature summary for 1.14.14.137 extracted from

  • Todoroki, Y.; Aoyama, H.; Hiramatsu, S.; Shirakura, M.; Nimitkeatkai, H.; Kondo, S.; Ueno, K.; Mizutani, M.; Hirai, N.
    Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8-hydroxylase CYP707A (2009), Bioorg. Med. Chem. Lett., 19, 5782-5786.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
a truncated CYP707A3 (707A3d28), which lacks the putative membrane-spanning segment of the N-terminus (residues 3–28) coexpressed in Escherichia coli strain BL21 with Arabidopsis P450 reductase Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
(1E)-1-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
(1E)-1-[4-(4-heptyl-1H-1,2,3-triazol-1-yl)phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 96% Arabidopsis thaliana
(1E)-1-[4-[4-(1-hydroxybutyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 92% Arabidopsis thaliana
(1E)-1-[4-[4-(1-hydroxyethyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 77% Arabidopsis thaliana
(1E)-1-[4-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 83% Arabidopsis thaliana
(1E)-4,4-dimethyl-1-[4-(4-nonyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
(1E)-4,4-dimethyl-1-[4-(4-pentadecyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 54% Arabidopsis thaliana
(1E)-4,4-dimethyl-1-[4-(4-propyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 92% Arabidopsis thaliana
(1E)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-[4-(4-tridecyl-1H-1,2,3-triazol-1-yl)phenyl]pent-1-en-3-ol 0.01 mM, inhibits by 95% Arabidopsis thaliana
(1E)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-[4-(4-undecyl-1H-1,2,3-triazol-1-yl)phenyl]pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
4-(1-[4-[(1E)-3-hydroxy-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-1-yl]phenyl]-1H-1,2,3-triazol-4-yl)butanoic acid 0.01 mM, inhibits by 63% Arabidopsis thaliana
S-UNI inhibits by 100% Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
(+)-abscisic acid
-
Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
Arabidopsis thaliana 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
ABA 8'-hydroxylase
-
Arabidopsis thaliana
abscisic acid 8'-hydroxylase
-
Arabidopsis thaliana
CYP707A3
-
Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00001
-
S-UNI
-
Arabidopsis thaliana
0.000195
-
4-(1-[4-[(1E)-3-hydroxy-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-1-yl]phenyl]-1H-1,2,3-triazol-4-yl)butanoic acid
-
Arabidopsis thaliana