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Literature summary for 1.14.14.137 extracted from

  • Todoroki, Y.; Kobayashi, K.; Yoneyama, H.; Hiramatsu, S.; Jin, M.H.; Watanabe, B.; Mizutani, M.; Hirai, N.
    Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8-hydroxylase, with a focus on hydrophilic functional groups and conformation (2008), Bioorg. Med. Chem., 16, 3141-3152.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-1-(1-(4-chlorophenyl)-3-fluoro-4,4-dimethylpent-1-en-2-yl)-1H-1,2,4-triazole i.e. UNI-F Arabidopsis thaliana
(E)-1-(1-(4-chlorophenyl)-4,4-dimethylpent-1-en-2-yl)-1H-imidazole i.e. IMI-H Arabidopsis thaliana
(S,E)-1-(1-(4-chlorophenyl)-3-fluoro-4,4-dimethylpent-1-en-2-yl)-1H-imidazole i.e. IMI-F Arabidopsis thaliana
(S,E)-1-(1-(4-chlorophenyl)-3-methoxy-4,4-dimethylpent-1-en-2-yl)-1H-imidazole i.e. IMI-OMe Arabidopsis thaliana
(Z)-1-(1-(4-chlorophenyl)-4,4-dimethylpent-1-en-2-yl)-1H-imidazole
-
Arabidopsis thaliana
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpentan-1-ol
-
Arabidopsis thaliana
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpentan-1-one
-
Arabidopsis thaliana
S-uniconazole i.e. S-(+)-E-1-(4-chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazo-1-yl)-1-penten-3-ol or UNI-OH, an azole-containing P450 inhibitor and a plant growth retardant, is a strong inhibitor of the enzyme, structure-activity relationship, the main site of action of UNI-OH is suggested to be ent-kaurene oxidase, EC 1.14.13.78, UNI-OH also inhibits brassinosteroid biosynthesis, and alters the level of other plant hormones, such as auxins, cytokinins, ethylene, and abscisic acid, overview Arabidopsis thaliana
UNI-H
-
Arabidopsis thaliana
UNI-OMe
-
Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Arabidopsis thaliana
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2 Arabidopsis thaliana key enzyme in abscisic acid catabolism 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
Arabidopsis thaliana 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2 key enzyme in abscisic acid catabolism Arabidopsis thaliana 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
ABA 8-hydroxylase
-
Arabidopsis thaliana
CYP707A3
-
Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.3
-
Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, computational methods, overview Arabidopsis thaliana
0.0012
-
(S,E)-1-(1-(4-chlorophenyl)-3-methoxy-4,4-dimethylpent-1-en-2-yl)-1H-imidazole pH 7.2-7.3, 30°C, recombinant enzyme Arabidopsis thaliana
0.0027
-
S-(+)-uniconazole pH 7.2-7.3, 30°C, recombinant enzyme Arabidopsis thaliana
0.0086
-
UNI-OMe pH 7.2-7.3, 30°C, recombinant enzyme Arabidopsis thaliana
0.034
-
UNI-H pH 7.2-7.3, 30°C, recombinant enzyme Arabidopsis thaliana
0.034
-
(E)-1-(1-(4-chlorophenyl)-3-fluoro-4,4-dimethylpent-1-en-2-yl)-1H-1,2,4-triazole pH 7.2-7.3, 30°C, recombinant enzyme Arabidopsis thaliana