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Literature summary for 1.14.14.127 extracted from

  • Abrisqueta, M.; Sueren-Castillo, S.; Maestro, J.L.
    Insulin receptor-mediated nutritional signalling regulates juvenile hormone biosynthesis and vitellogenin production in the German cockroach (2014), Insect Biochem. Mol. Biol., 49, 14-23 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP15A1, RT-PCR enzyme expression analysis Blattella germanica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Blattella germanica
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Blattella germanica D6CJJ9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus allatum
-
Blattella germanica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
Blattella germanica juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP15A1
-
Blattella germanica
CYP15A1 protein
-
Blattella germanica

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Blattella germanica
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Blattella germanica

Expression

Organism Comment Expression
Blattella germanica starving reduces the enzyme expression down

General Information

General Information Comment Organism
malfunction BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview Blattella germanica
metabolism the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway Blattella germanica