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Literature summary for 1.14.14.127 extracted from

  • Jedlicka, P.; Ernst, U.; Votavova, A.; Hanus, R.; Valterova, I.
    Gene expression dynamics in major endocrine regulatory pathways along the transition from solitary to social life in a bumblebee, Bombus terrestris (2016), Front. Physiol., 7, 574 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene MFE, quantitative RT-PCR enzyme expression analysis Bombus terrestris terrestris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Bombus terrestris terrestris
-
 juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bombus terrestris terrestris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bombus terrestris terrestris
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crop
-
 Bombus terrestris terrestris
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fat body
-
 Bombus terrestris terrestris
-
flight muscle
-
 Bombus terrestris terrestris
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gonad
-
 Bombus terrestris terrestris
-
labial gland
-
 Bombus terrestris terrestris
-
additional information expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview Bombus terrestris terrestris
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ovary of workers and reproducing queens, high MFE expression in ovaries of bumblebee females Bombus terrestris terrestris
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rectum
-
 Bombus terrestris terrestris
-
ventriculus
-
 Bombus terrestris terrestris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
 Bombus terrestris terrestris juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MFE
-
 Bombus terrestris terrestris

Cofactor

Cofactor Comment Organism Structure
NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Bombus terrestris terrestris

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the final step of juvenile hormone III biosynthesis Bombus terrestris terrestris
physiological function the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level Bombus terrestris terrestris