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Literature summary for 1.14.14.124 extracted from

  • Nakamura, T.; Komagata, D.; Murakawa, S.; Sakai, K.; Endo, A.
    Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L (1990), J. Antibiot., 43, 1597-1600.
    View publication on PubMed
Search for more literature for 1.14.14.124

Organism

Organism UniProt Comment Textmining
Monascus ruber
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Reaction

Reaction Comment Organism Reaction ID
3alpha-hydroxy-3,5-dihydromonacolin L acid = monacolin L acid + H2O (1b), spontaneous Monascus ruber
a
dihydromonacolin L acid + O2 + [reduced NADPH-hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O (1a) Monascus ruber
a
dihydromonacolin L acid + O2 + [reduced NADPH-hemoprotein reductase] = monacolin L acid + [oxidized NADPH-hemoprotein reductase] + 2 H2O (overall reaction) Monascus ruber
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-hydroxy-3,5-dihydromonacolin L acid spontaneous Monascus ruber monacolin L acid + H2O (1b), spontaneous ?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate Monascus ruber 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 reaction of cell free extract in presence of air Monascus ruber 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Monascus ruber monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a heme-thiolate protein Monascus ruber