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Literature summary for 1.14.14.120 extracted from

  • Han, J.Y.; Kim, H.J.; Kwon, Y.S.; Choi, Y.E.
    The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng (2011), Plant Cell Physiol., 52, 2062-2073.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain WAT21 Panax ginseng

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dammarenediol-II + [reduced NADPH-hemoprotein reductase] + O2 Panax ginseng
-
 protopanaxadiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Panax ginseng
-
 cultivar C.A. Meyer
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Panax ginseng
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dammarenediol-II + [reduced NADPH-hemoprotein reductase] + O2
-
 Panax ginseng protopanaxadiol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP716A47
-
 Panax ginseng
dammarenediol 12-hydroxylase
-
 Panax ginseng
protopanaxadiol synthase
-
 Panax ginseng

Expression

Organism Comment Expression
Panax ginseng the gene is transcriptionally activated not only by methyl jasmonate treatment but also in transgenic ginseng that overexpresses squalene synthase and overproduces ginsenosides up