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Literature summary for 1.14.14.119 extracted from

  • Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.
    Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus (2009), ChemBioChem, 10, 920-928.
    View publication on PubMed
Search for more literature for 1.14.14.119

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 Aspergillus fumigatus the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 Aspergillus fumigatus BM939 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus B9WZX6
-
-
Aspergillus fumigatus BM939 B9WZX6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
-
 Aspergillus fumigatus 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
-
 Aspergillus fumigatus BM939 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus BM939 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
ftmG
-
 Aspergillus fumigatus

Cofactor

Cofactor Comment Organism Structure
heme heme-thiolate protein (P-450) Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction the disruption of ftmG results in the loss of production of 12alpha,13alpha-dihydroxyfumitremorgin C and fumitremorgin B Aspergillus fumigatus
physiological function the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus