Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.102 extracted from

  • Desgagne-Penix, I.; Facchini, P.
    Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy (2012), Plant J., 72, 331-344.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 Papaver somniferum
-
(S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2
-
Papaver somniferum (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
N-methylcoclaurine 3'-hydroxylase
-
Papaver somniferum
NMCH
-
Papaver somniferum

General Information

General Information Comment Organism
malfunction enzyme silencing is associated with a 22% reduction in total alkaloid accumulation, with a notable decrease in the levels of thebaine and codeine compared with controls. In contrast, absolute levels of morphine and papaverine are not affected Papaver somniferum