Application | Comment | Organism |
---|---|---|
biotechnology | the enzyme provides practical means to genetically engineer valuable secondary metabolites in this important medicinal plant | Papaver somniferum |
Cloned (Comment) | Organism |
---|---|
gene cyp80b3, overexpression in Papaver somniferum plants, expression of anti-sense constructs, construction of transgenic plants using the Agrobacterium tumefaciens, strain AGL1, transfection method, expression of antisense cyp80b3 leads to a reduction of total alkaloid in latex up to 84%, phenotype, overview, enzyme overexpression results in an up to 450% increase in the amount of total alkaloid in latex without changing the ratio of the individual alkaloids, or together with an overall increase in the ratio of morphine | Papaver somniferum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a cytochrome P450 enzyme | Papaver somniferum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | Papaver somniferum | the enzyme catalyzes a key regulation step in morphine biosynthesis | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | - |
cv. C048-6-14-64 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Papaver somniferum | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme catalyzes a key regulation step in morphine biosynthesis | Papaver somniferum | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(S)-N-methylcoclaurine 3'-hydroxylase | - |
Papaver somniferum |
CYP80B3 | - |
Papaver somniferum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | dependent on | Papaver somniferum |