Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CYP80B1 is rapidly induced to high levels in response to fungal elicitor treatment | Papaver somniferum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | membrane-bound, CYP80B1 from opium poppy contains a noncleavable N-terminal ER-signal peptide | Papaver somniferum | 5789 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | P450-dependent hydroxylase | Papaver somniferum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | Papaver somniferum | one of the key enzymes in biosynthesis of benzylisoquinoline alkaloids in the opium poppy, CYP80B1 catalyzes the second to last step in the formation of (S)-reticuline, the last common intermediate in sanguinarine and morphine biosynthesis, overview | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Papaver somniferum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Papaver somniferum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | one of the key enzymes in biosynthesis of benzylisoquinoline alkaloids in the opium poppy, CYP80B1 catalyzes the second to last step in the formation of (S)-reticuline, the last common intermediate in sanguinarine and morphine biosynthesis, overview | Papaver somniferum | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 | specific for the substrate | Papaver somniferum | (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(S)-N-methylcoclaurine 3'-hydroxylase | - |
Papaver somniferum |
CYP80B1 | - |
Papaver somniferum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | P450-dependent hydroxylase | Papaver somniferum |