Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.102 extracted from

  • Alcantara, J.; Bird, D.A.; Franceschi, V.R.; Facchini, P.J.
    Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment (2005), Plant Physiol., 138, 173-183.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information CYP80B1 is rapidly induced to high levels in response to fungal elicitor treatment Papaver somniferum

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane membrane-bound, CYP80B1 from opium poppy contains a noncleavable N-terminal ER-signal peptide Papaver somniferum 5789
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ P450-dependent hydroxylase Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 Papaver somniferum one of the key enzymes in biosynthesis of benzylisoquinoline alkaloids in the opium poppy, CYP80B1 catalyzes the second to last step in the formation of (S)-reticuline, the last common intermediate in sanguinarine and morphine biosynthesis, overview (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Papaver somniferum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 one of the key enzymes in biosynthesis of benzylisoquinoline alkaloids in the opium poppy, CYP80B1 catalyzes the second to last step in the formation of (S)-reticuline, the last common intermediate in sanguinarine and morphine biosynthesis, overview Papaver somniferum (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 specific for the substrate Papaver somniferum (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
(S)-N-methylcoclaurine 3'-hydroxylase
-
Papaver somniferum
CYP80B1
-
Papaver somniferum

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 P450-dependent hydroxylase Papaver somniferum