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Literature summary for 1.14.14.1 extracted from
- Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems (2020), Environ. Toxicol. Pharmacol., 74, 103310 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P08683 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| vandetanib + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Rattus norvegicus | N-desmethylvandetanib + [oxidized NADPH-hemoprotein reductase] + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP2C11 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | when NADH is used together with NADPH in the incubation mixture, CYP2C11 produces up to 1.2times higher levels of N-desmethylvandetanib | Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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