Literature summary for 1.14.14.1 extracted from

Hasegawa, E.; Inafuku, S.; Mulki, L.; Okunuki, Y.; Yanai, R.; Smith, K.; Kim, C.; Klokman, G.; Bielenberg, D.; Puli, N.; Falck, J.; Husain, D.; Miller, J.; Edin, M.; Zeldin, D.; Lee, K.; Hammock, B.; Schunck, W.; Connor, K.
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization (2017), Proc. Natl. Acad. Sci. USA, 114, E7545-E7553 .

Search for more literature for 1.14.14.1

Application

Application	Comment	Organism
medicine	in transgenic mice with altered cytochrome P450 lipid biosynthetic pathways in a mouse model of laser-induced choroidal neovascularization, overexpression of the human monooxygenase CYP2C8 or genetic ablation or inhibition of the soluble epoxide hydrolase enzyme leads to increased levels of epoxydocosapentaenoic acids and epoxyeicosatetraenoic acids with attenuated choroidal neovascularization development. The molecules work in part through their ability to regulate the expression of key leukocyte adhesion molecules, on both leukocytes and endothelial cells, thereby mediating leukocyte recruitment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
CYP2C8	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	in transgenic mice with altered cytochrome P450 lipid biosynthetic pathways in a mouse model of laser-induced choroidal neovascularization, overexpression of the human monooxygenase CYP2C8 or genetic ablation or inhibition of the soluble epoxide hydrolase enzyme leads to increased levels of epoxydocosapentaenoic acids and epoxyeicosatetraenoic acids with attenuated choroidal neovascularization development	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)