Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.1 extracted from

  • Matowane, R.; Wieteska, L.; Bamal, H.; Kgosiemang, I.; Van Wyk, M.; Manume, N.; Abdalla, S.; Mashele, S.; Gront, D.; Syed, K.
    In silico analysis of cytochrome P450 monooxygenases in chrgranulomatous infectious fungus onic Sporothrix schenckii Special focus on CYP51 (2018), Biochim. Biophys. Acta, 1866, 166-177 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
3D modeling of CYP51, presence of characteristic P450 motifs with a exceptionally large reductase interaction site 2. A number of mutations can be associated with ketoconazole resistance, especially at the channel entrance to the active site. Better stabilization of itraconazole, compared to ketoconazole, maybe due to a hydrogen bond with residue Asn230 Sporothrix schenckii

Organism

Organism UniProt Comment Textmining
Sporothrix schenckii U7Q7I7
-
-
Sporothrix schenckii ATCC 58251 U7Q7I7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ketoconazole + reduced flavoprotein + O2
-
Sporothrix schenckii ? + oxidized flavoprotein + H2O
-
?
ketoconazole + reduced flavoprotein + O2
-
Sporothrix schenckii ATCC 58251 ? + oxidized flavoprotein + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP51
-
Sporothrix schenckii
HMPREF1624_01477
-
Sporothrix schenckii

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Sporothrix schenckii