Crystallization (Comment) | Organism |
---|---|
3D modeling of CYP51, presence of characteristic P450 motifs with a exceptionally large reductase interaction site 2. A number of mutations can be associated with ketoconazole resistance, especially at the channel entrance to the active site. Better stabilization of itraconazole, compared to ketoconazole, maybe due to a hydrogen bond with residue Asn230 | Sporothrix schenckii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sporothrix schenckii | U7Q7I7 | - |
- |
Sporothrix schenckii ATCC 58251 | U7Q7I7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ketoconazole + reduced flavoprotein + O2 | - |
Sporothrix schenckii | ? + oxidized flavoprotein + H2O | - |
? | |
ketoconazole + reduced flavoprotein + O2 | - |
Sporothrix schenckii ATCC 58251 | ? + oxidized flavoprotein + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Sporothrix schenckii |
HMPREF1624_01477 | - |
Sporothrix schenckii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Sporothrix schenckii |