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Literature summary for 1.14.14.1 extracted from

  • Kolrep, F.; Hessel, S.; These, A.; Ehlers, A.; Rein, K.; Lampen, A.
    Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases (2016), Arch. Toxicol., 90, 2025-2036 .
    View publication on PubMed
Search for more literature for 1.14.14.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in HepG2 cells Homo sapiens
expression in HepG2 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole
-
 Homo sapiens
ketoconazole
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus P04799
-
-
Rattus norvegicus P04800
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
okadaic acid + NADPH + O2
-
 Homo sapiens ?
-
 ?
okadaic acid + NADPH + O2
-
 Rattus norvegicus ?
-
 ?
okadaic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus ? + [oxidized NADPH-hemoprotein reductase]
-
 ?

Synonyms

Synonyms Comment Organism
CYP1A2
-
 Homo sapiens
CYP1A2
-
 Rattus norvegicus
CYP3A1
-
 Rattus norvegicus
CYP3A4
-
 Homo sapiens
CYP3A5
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism metabolism of okadaic acid to oxygenated metabolites correlates with detoxification by Cyp3A enzymes. The okadaic acid toxicity is enhanced in the presence of rat CYP1A2 Rattus norvegicus
metabolism metabolism of okadaic acid to oxygenated metabolites correlates with detoxification by Cyp3A enzymes. The rate of detoxification by rat Cyp3a1 is lower compared to human CYP3A enzymes Rattus norvegicus
metabolism metabolism of okadaic acid to oxygenated metabolites correlates with detoxification which is mainly catalyzed by human CYP3A4 and CYP3A5. Human isoform CYP1A2 seems to activate okadaic acid into cytotoxic intermediates Homo sapiens
metabolism metabolism of okadaic acid to oxygenated metabolites correlates with detoxification which is mainly catalyzed by human CYP3A4 and CYP3A5. The coincubation of okadaic acid with human CYP3A4 results in an increase in HepG2 cell viability. Human isoform CYP1A2 seems to activate okadaic acid into cytotoxic intermediates Homo sapiens
metabolism metabolism of okadaic acid to oxygenated metabolites correlates with detoxification which is mainly catalyzed by human CYP3A4 and CYP3A5. The okadaic acid toxicity is enhanced in the presence of human CYP1A2 Homo sapiens