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Literature summary for 1.14.14.1 extracted from

  • Zhang, X.; Moore, J.N.; Newsted, J.L.; Hecker, M.; Zwiernik, M.J.; Jones, P.D.; Bursian, S.J.; Giesy, J.P.
    Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds (2009), Toxicol. Appl. Pharmacol., 234, 306-313.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Neogale vison

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Neogale vison
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57900
-
 sequence analysis Neogale vison
58500
-
 sequence analysis Neogale vison

Organism

Organism UniProt Comment Textmining
Neogale vison A7UDB5
-
-
Neogale vison A7UDB6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Neogale vison
-
lung
-
 Neogale vison
-

Synonyms

Synonyms Comment Organism
CYP1A1
-
 Neogale vison
CYP1A2
-
 Neogale vison

Expression

Organism Comment Expression
Neogale vison exposure to both 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran results in dose-dependent increase of CYP1A2 mRNA due to an underlying aryl hydrocarbon receptor-mediated mechanism up
Neogale vison exposure to both 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran results in dose-dependent increases of CYP1A1 mRNA and CYP1A protein levels due to an underlying aryl hydrocarbon receptor-mediated mechanism. Upregulation of CYP1A mRNA in liver is more consistent to the sum adipose 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentration than to the liver 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentration in minks treated with 2,3,7,8-tetrachlorodibenzofuran or 2,3,4,7,8-pentachlorodibenzofuran up