Activating Compound | Comment | Organism | Structure |
---|---|---|---|
anastrozole | increases labeling of P450 1A2 by probe 3 up to 175% of control values | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
recombinant cDNA P450s coexpressed with cytochrome P450 reductase in insect cell microsomes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17alpha-ethynylestradiol | reactive intermediates of 17alpha-ethynylestradiol inactivate P450s in a NADPH-dependent mechanism-based manner by a combination of heme alkylation and apoprotein modification | Homo sapiens | |
8-methoxypsoralen | - |
Homo sapiens | |
anastrozole | profiling inhibition of probe 1 labeling of P450 19A1, inhibits labeling of P450 2C9 by probe 5 | Homo sapiens | |
formestane | profiling inhibition of probe 1 labeling of P450 19A1, decreases probe 5 labeling of P450 2C19 and 1 labeling of P450 3A4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | reacts with activity-based proteins of varying chemical composition, quite distinct from their natural substrates | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aromatase | - |
Homo sapiens |
P450 19A1 | - |
Homo sapiens |
P450 1A1 | - |
Homo sapiens |
P450 1A2 | - |
Homo sapiens |
P450 1B1 | - |
Homo sapiens |
P450 2A6 | - |
Homo sapiens |
P450 2B6 | - |
Homo sapiens |
P450 2C19 | - |
Homo sapiens |
P450 2C9 | - |
Homo sapiens |
P450 2D6 | - |
Homo sapiens |
P450 2E1 | - |
Homo sapiens |
P450 2J2 | - |
Homo sapiens |
P450 3A4 | - |
Homo sapiens |
P450 4A11 | - |
Homo sapiens |
P450 4F2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00043 | - |
P450 19A1 | Homo sapiens | formestane | |
0.001 | - |
P450 19A1 | Homo sapiens | anastrozole |
General Information | Comment | Organism |
---|---|---|
physiological function | P450 1B1 is able to activate a broad spectrum of chemical carcinogens, including polycyclic hydrocarbons and heterocyclic and aromatic amines | Homo sapiens |