Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonic acid + O2 + NADPH | Homo sapiens | - |
20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
arachidonic acid + O2 + NADPH | Rattus norvegicus | - |
20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
additional information | Homo sapiens | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview | ? | - |
? | |
additional information | Rattus norvegicus | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview, PPARalpha agonist increased the transcription activity of rat CYP4A1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several isozymes, e.g. CYP4F and CYP4A | - |
Rattus norvegicus | - |
several isozymes, e.g. CYP4F and CYP4A, 9-week-old, male Sprague-Dawley rats | - |
Purification (Comment) | Organism |
---|---|
partially by microsome preparation | Homo sapiens |
partially by microsome preparation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | especially in proximal tubule, lower expression in the preglomerular microvessel, glomerulus and thick ascending limb | Homo sapiens | - |
kidney | especially in proximal tubule, lower expression in the preglomerular microvessel, glomerulus and thick ascending limb | Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
additional information | isozyme tissue-specific expression analysis, regulation by PPAR | Homo sapiens | - |
additional information | isozyme tissue-specific expression analysis, regulation by PPAR | Rattus norvegicus | - |
renal cortex | - |
Homo sapiens | - |
renal cortex | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonic acid + O2 + NADPH | - |
Homo sapiens | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
arachidonic acid + O2 + NADPH | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
arachidonic acid + O2 + NADPH | - |
Homo sapiens | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e.20-HETE | ? | |
arachidonic acid + O2 + NADPH | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e.20-HETE | ? | |
additional information | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview | Homo sapiens | ? | - |
? | |
additional information | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview, PPARalpha agonist increased the transcription activity of rat CYP4A1 | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000-52000, CYP4A isoforms, SDS-PAGE | Homo sapiens |
? | x * 50000-52000, CYP4A isoforms, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
CYP4 | - |
Homo sapiens |
CYP4 | - |
Rattus norvegicus |
CYP4A | - |
Homo sapiens |
CYP4A | - |
Rattus norvegicus |
CYP4F | - |
Homo sapiens |
CYP4F | - |
Rattus norvegicus |
cytochrome P-450 4 enzyme | - |
Homo sapiens |
cytochrome P-450 4 enzyme | - |
Rattus norvegicus |