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Literature summary for 1.14.14.1 extracted from

  • Johnson, E.F.; Stout, C.D.
    Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases (2005), Biochem. Biophys. Res. Commun., 338, 331-336.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of human CYPS, overvuew, expression in Escherichia coli without the N-terminal leader sequence Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the majority of human P450s are targeted to the endoplasmic reticulum by a leader sequence that forms a transmembrane helix that anchors microsomal P450s to the cytoplasmic surface of the endoplasmic reticulum Homo sapiens 5783
-
microsome P450s generally exhibit membrane targeting sequences that precede the catalytic domain Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ heme iron Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products ?
-
?
additional information Homo sapiens a xenobiotic-metabolizing cytochrome P450 monooxygenase that contributes extensively to drug and toxin metabolism, CYP3A4 is the predominant enzyme in the clearance of about 50% of therapeutic drugs ?
-
?
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O active site structures and function-structure relationships of CYPS Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products Homo sapiens ?
-
?
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 nicotine oxidase activity of CYP2A6 Homo sapiens ?
-
?
additional information a xenobiotic-metabolizing cytochrome P450 monooxygenase that contributes extensively to drug and toxin metabolism, CYP3A4 is the predominant enzyme in the clearance of about 50% of therapeutic drugs Homo sapiens ?
-
?
additional information substrates bind in a cavity above the heme surface, function-structure relationship, the outer surfaces of the active site cavity are formed by portions of beta-sheets 1 and 4, helices F–G, and the loop between helices B and C, overview Homo sapiens ?
-
?
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products Homo sapiens ?
-
?
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 nicotine oxidase activity of CYP2A6 Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More secondary and tertiary structures of CYPs, a short hydrophilic linker region between the transmembrane domain and the catalytic domain which begins with the proline rich sequence motif, overview, function-structure relationship Homo sapiens

Synonyms

Synonyms Comment Organism
Cyp
-
Homo sapiens
CYP2A6
-
Homo sapiens
CYP2C8
-
Homo sapiens
CYP2C9
-
Homo sapiens
CYP3A4
-
Homo sapiens
cytochrome P450 monooxygenase 2A6
-
Homo sapiens
cytochrome P450 monooxygenase 2C8
-
Homo sapiens
cytochrome P450 monooxygenase 2C9
-
Homo sapiens
cytochrome P450 monooxygenase 3A4
-
Homo sapiens
nicotine oxidase CYP2A6 Homo sapiens
P450
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
flavoprotein
-
Homo sapiens