Cloned (Comment) | Organism |
---|---|
expression analysis of human CYPS, overvuew, expression in Escherichia coli without the N-terminal leader sequence | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | the majority of human P450s are targeted to the endoplasmic reticulum by a leader sequence that forms a transmembrane helix that anchors microsomal P450s to the cytoplasmic surface of the endoplasmic reticulum | Homo sapiens | 5783 | - |
microsome | P450s generally exhibit membrane targeting sequences that precede the catalytic domain | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | heme iron | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products | ? | - |
? | |
additional information | Homo sapiens | a xenobiotic-metabolizing cytochrome P450 monooxygenase that contributes extensively to drug and toxin metabolism, CYP3A4 is the predominant enzyme in the clearance of about 50% of therapeutic drugs | ? | - |
? | |
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O | active site structures and function-structure relationships of CYPS | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 | nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products | Homo sapiens | ? | - |
? | |
4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 | nicotine oxidase activity of CYP2A6 | Homo sapiens | ? | - |
? | |
additional information | a xenobiotic-metabolizing cytochrome P450 monooxygenase that contributes extensively to drug and toxin metabolism, CYP3A4 is the predominant enzyme in the clearance of about 50% of therapeutic drugs | Homo sapiens | ? | - |
? | |
additional information | substrates bind in a cavity above the heme surface, function-structure relationship, the outer surfaces of the active site cavity are formed by portions of beta-sheets 1 and 4, helices FÂG, and the loop between helices B and C, overview | Homo sapiens | ? | - |
? | |
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 | nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products | Homo sapiens | ? | - |
? | |
N'-nitrosonornicotine + [reduced NADPH-hemoprotein reductase] + O2 | nicotine oxidase activity of CYP2A6 | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | secondary and tertiary structures of CYPs, a short hydrophilic linker region between the transmembrane domain and the catalytic domain which begins with the proline rich sequence motif, overview, function-structure relationship | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Cyp | - |
Homo sapiens |
CYP2A6 | - |
Homo sapiens |
CYP2C8 | - |
Homo sapiens |
CYP2C9 | - |
Homo sapiens |
CYP3A4 | - |
Homo sapiens |
cytochrome P450 monooxygenase 2A6 | - |
Homo sapiens |
cytochrome P450 monooxygenase 2C8 | - |
Homo sapiens |
cytochrome P450 monooxygenase 2C9 | - |
Homo sapiens |
cytochrome P450 monooxygenase 3A4 | - |
Homo sapiens |
nicotine oxidase | CYP2A6 | Homo sapiens |
P450 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavoprotein | - |
Homo sapiens |