Literature summary for 1.14.13.9 extracted from

Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo (2009), J. Neurochem., 109, 316-325.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1S,2S)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylic acid	KMO inhibitor UPF 648, totally blocks KMO at 0.1 and 0.01 mM and is still highly active at 0.001 mM (81% inhibition). It reduces 3-hydroxykynurenine synthesis by 64% without affecting kynurenic acid formation. In neuron-depleted striata, UPF 648 decreases both 3-hydroxykynurenine and quinolinic acid production by 77% and 66%, respectively and also raises kynurenic acid synthesis by 27%. 0.1 mM UPF 648 blocks KMO in both lesioned and contralateral striatum, but does not interfere with KAT activity in either tissue	Rattus norvegicus
(S)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-azaphenalene-5-carboxylic acid	does not affect KMO activity significantly, 1 mM inhibits by 17%	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	lesioned and contralateral striatum	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-kynurenine + NADPH + O2	-	Rattus norvegicus	3-hydroxy-L-kynurenine + NADP+ + H2O	-	?

Synonyms

Synonyms	Comment	Organism
KMO	-	Rattus norvegicus

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Release 2023.1 (January 2023)