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Literature summary for 1.14.13.9 extracted from

  • Quan, G.; Kobayashi, I.; Kojima, K.; Uchino, K.; Kanda, T.; Sezutsu, H.; Shimada, T.; Tamura, T.
    Rescue of white egg 1 mutant by introduction of the wild-type Bombyx kynurenine 3-monooxygenase gene (2007), Insect Sci., 14, 85-92.
No PubMed abstract available

Application

Application Comment Organism
molecular biology wild-type KMO gene can be used as a marker gene for visually screening transgenic silkworms Bombyx mori
molecular biology the wild-type enzyme gene can be used as a marker gene for visually screening transgenic silkworms Bombyx mori

Protein Variants

Protein Variants Comment Organism
additional information enzyme deficiency leads to the white eyes and white eggs w-1 phenotype in mutant silkworms, it can be partially rescued by expression of wild-type enzyme under control of either the cytoplasmic actin gene promoter, A3KMO, or the native KMO gene promoter, KKMO, phenotypes, overview Bombyx mori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + NADPH + H+ + O2 Bombyx mori
-
3-hydroxy-L-kynurenine + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bombyx mori
-
-
-
Bombyx mori Q95NK3
-
-
Bombyx mori C108
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fat body
-
Bombyx mori
-
fat body enzyme expression Bombyx mori
-
larva
-
Bombyx mori
-
malpighian tubule
-
Bombyx mori
-
malpighian tubule enzyme expression Bombyx mori
-
midgut
-
Bombyx mori
-
midgut enzyme expression Bombyx mori
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + NADPH + H+ + O2
-
Bombyx mori 3-hydroxy-L-kynurenine + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
KMO
-
Bombyx mori

General Information

General Information Comment Organism
physiological function the white egg 1 mutant, which is characterized by white eyes and white eggs, is deficient in Bombyx kynurenine 3-monooxygenase activity.Expression of the wild-type gene under control of either the cytoplasmic actin gene promoter (A3KMO) or the native KMO gene promoter (KKMO) leads to adults with brown eyes, and the eggs laid by the transgenic females are also brown. The A3KMO silkworm lines express the transcript in the mid-gut, fat bodies, and Malpighian tubules. The KKMO line expresses the transcript only in the fat bodies and Malpighian tubules. The intensity of eye and egg color in the transgenic lines is proportional to the KMO expression level Bombyx mori