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Literature summary for 1.14.13.9 extracted from

  • Ceresoli-Borroni, G.; Guidetti, P.; Amori, L.; Pellicciari, R.; Schwarcz, R.
    Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications (2007), J. Neurosci. Res., 85, 845-854.
    View publication on PubMed
Search for more literature for 1.14.13.9

Inhibitors

Inhibitors Comment Organism Structure
UPF 648 in vivo inhibition Mus musculus
UPF 648 in vivo inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kynurenine + NADPH + O2 Mus musculus enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
kynurenine + NADPH + O2 Rattus norvegicus enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
additional information Mus musculus the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, newborn mice delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview ?
-
 ?
additional information Rattus norvegicus the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynurenine + NADPH + O2
-
 Mus musculus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
kynurenine + NADPH + O2 enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview Mus musculus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
kynurenine + NADPH + O2 enzyme inhibition in immature rats shifts cerebral kynurenine pathway metabolism toward increased kynurenic acid formation, overview Rattus norvegicus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
additional information the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, newborn mice delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview Mus musculus ?
-
 ?
additional information the kynurenine pathway of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid and, in a competing branch, the free radical generator 3-hydroxykynurenine and the excitotoxin quinolinic acid, rat pups delivered by UPF 648-treated mothers and immediately exposed to neonatal asphyxia show further enhanced brain kynurenic acid levels, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
kynurenine 3-hydroxylase
-
 Mus musculus
kynurenine 3-hydroxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Rattus norvegicus