Literature summary for 1.14.13.9 extracted from

Rover, S.; Cesura, A.M.; Huguenin, P.; Kettler, R.; Szente, A.
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase (1997), J. Med. Chem., 40, 4378-4385.

Search for more literature for 1.14.13.9

Inhibitors

Inhibitors	Comment	Organism	Structure
(R,S)-2-amino-oxo-4-(3'-4'-dichlorophenyl)butanoic acid	-	Rattus norvegicus
3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide	Ro-61-8048, 50% inhibition at 37 nM	Rattus norvegicus
4-amino-N-[4-[2-fluoro-5-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide	50% inhibition at 19nM	Rattus norvegicus
additional information	inhibition by N-(4-phenylthiazol-2-yl)benzenesulfonamides with various modifications	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000048	-	3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide	competitive inhibitor	Rattus norvegicus
0.000095	-	(R,S)-2-amino-oxo-4-(3'-4'-dichlorophenyl)butanoic acid	competitive inhibitor	Rattus norvegicus

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Release 2023.1 (January 2023)