Any feedback?
Literature summary for 1.14.13.9 extracted from
- Studies on oxygenases: Enzymatic formation of 3-hydroxy-L-kynurenine from L-kynurenine (1957), J. Biol. Chem., 229, 921-934.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| azide | 0.005 M | Rattus norvegicus |  |
| thiocyanate | 0.01 M | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CN- | inhibition at 0.01 M | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.023 | - |
NADPH | - |
Rattus norvegicus | |
| 0.025 | - |
kynurenine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Br- | strong stimulation | Rattus norvegicus | |
| Cl- | strong stimulation at 0.02 M | Rattus norvegicus | |
| CN- | stimulates | Rattus norvegicus | |
| F- | stimulates | Rattus norvegicus | |
| I- | stimulates | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + NADPH + O2 | Rattus norvegicus | - |
? + NADP+ | - |
? | |
| L-kynurenine + NADPH + O2 | Rattus norvegicus Osborne-Mendel | - |
? + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Osborne-Mendel strain | - |
| Rattus norvegicus Osborne-Mendel | - |
Osborne-Mendel strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + NADPH + O2 | no reaction with D-isomer | Rattus norvegicus | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
| L-kynurenine + NADPH + O2 | no reaction with D-isomer | Rattus norvegicus Osborne-Mendel | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
| L-kynurenine + NADPH + O2 | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| L-kynurenine + NADPH + O2 | - |
Rattus norvegicus Osborne-Mendel | ? + NADP+ | - |
? | |
| o-hydroxybenzoyl-DL-alanine + NADPH + O2 | about 25% of the activity with L-kynurenine | Rattus norvegicus | ? + NADP+ | - |
? | |
| o-hydroxybenzoyl-DL-alanine + NADPH + O2 | about 25% of the activity with L-kynurenine | Rattus norvegicus Osborne-Mendel | ? + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9.3 | about 50% of maximal activity at pH 7 and 9.3 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | flavoprotein | Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
