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Literature summary for 1.14.13.8 extracted from

  • Matsumoto, K.; Hasegawa, T.; Ohara, K.; Kamei, T.; Koyanagi, J.; Akimoto, M.
    Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro (2021), Xenobiotica, 51, 155-166 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-nabumetone + NADPH + H+ + O2 Homo sapiens activation reaction ? + NADP+ + H2O
-
?
N,N-dimethylaniline + NADPH + H+ + O2 Homo sapiens
-
N,N-dimethylaniline N-oxide + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49326
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-nabumetone + NADPH + H+ + O2 activation reaction Homo sapiens ? + NADP+ + H2O
-
?
N,N-dimethylaniline + NADPH + H+ + O2
-
Homo sapiens N,N-dimethylaniline N-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase
-
Homo sapiens
flavin-containing monooxygenase 5
-
Homo sapiens
hFMO5
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
physiological function role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of (4-(6-methoxynaphthalen-2-yl)butan-2-one, NAB): Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy-nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) in vitro. The reaction involves carbon-carbon cleavage catalyzed by the Baeyer-Villiger oxidation (BVO) of a carbonyl compound, the BVO substrate, such as a ketol, by FMO5. Further in vitro inhibition experiments show that multiple non-CYP enzymes are involved in the formation of 6-MNA from 3-OH-NAB in human hepatocytes. NAB is a substrate for CYP1A2, CYP3A4, and CYP2J2. In the extract obtained from 3-hydroxy-nabumetone (3-OH-NAB) by a combined incubation of recombinant human FMO5 and human liver S9 Homo sapiens