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Literature summary for 1.14.13.8 extracted from

  • Shimizu, M.; Uehara, S.; Suemizu, H.; Yamazaki, H.
    In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice (2021), Drug Metab. Pharmacokinet., 37, 100369 .
    View publication on PubMed
Search for more literature for 1.14.13.8

Protein Variants

Protein Variants Comment Organism
additional information generation of humanized-liver TK-NOG mice, chimeric mice, in which more than 90% of liver cells are estimated to have been replaced with human hepatocytes, interactions between FMO substrates in humanized-liver mice, overview. Administered itopride (10 mg/kg) is extensively oxygenated to its N-oxide in humanized-liver mouse plasma. The area under the concentration-time curve of itopride N-oxide is 15fold that of itopride in humanize-liver mice Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
itopride + NADPH + H+ + O2 Homo sapiens
-
 itopride N-oxide + NADP+ + H2O
-
 ?
N,N-dimethylaniline + NADPH + H+ + O2 Homo sapiens
-
 N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?
trimethylamine + NADPH + H+ + O2 Homo sapiens
-
 trimethylamine N-oxide + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver human FMO3 protein is predominantly expressed in the liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
itopride + NADPH + H+ + O2
-
 Homo sapiens itopride N-oxide + NADP+ + H2O
-
 ?
N,N-dimethylaniline + NADPH + H+ + O2
-
 Homo sapiens N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?
trimethylamine + NADPH + H+ + O2
-
 Homo sapiens trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 3
-
 Homo sapiens
FMO3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction genetic mutations in FMO3 can cause trimethylaminuria (or fish-odor syndrome) as a result of impaired N-oxygenation of food-derived trimethylamine Homo sapiens
physiological function human FMO3 protein exhibits marked individual variability in oxygenation activities, analysis of in vivo pharmacokinetics of itopride and trimethylamine-d9 and their N-oxygenated metabolites after co-administrations in humanized-liver mice, modeling of physiologically based pharmacokinetic (PBPK) and formation of models for itopride and its N-oxide consisting of receptor (gut), metabolizing (liver), and central compartments, overview Homo sapiens