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Literature summary for 1.14.13.8 extracted from

  • Fennema, D.; Phillips, I.R.; Shephard, E.A.
    Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease (2016), Drug Metab. Dispos., 44, 1839-1850 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.8

Protein Variants

Protein Variants Comment Organism
E158K the mutant shows moderately reduced activity Homo sapiens
E308G the mutant shows moderately reduced activity Homo sapiens
L360P the mutation increases catalytic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trimethylamine + NADPH + H+ + O2
-
 Homo sapiens trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 3
-
 Homo sapiens
FMO3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens