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Literature summary for 1.14.13.8 extracted from

  • Fedejko-Kap, B.; Niemira, M.; Radominska-Pandya, A.; Mazerska, Z.
    Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells (2011), Xenobiotica, 41, 1044-1055.
    View publication on PubMed
Search for more literature for 1.14.13.8

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0229
-
 5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one isozyme FMO1, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C Homo sapiens
0.05903
-
 5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one isozyme FMO1, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C Homo sapiens
0.4314
-
 5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one isozyme FMO5, in 0.1 M potassium phosphate buffer (pH 8.4) at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01740 isozyme FMO1
-
Homo sapiens Q9HA79 isozyme FMO5
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. C-1305 Rattus norvegicus 5-[[3-(dimethylnitroryl)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. C-1305 Homo sapiens 5-[[3-(dimethylnitroryl)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. C-1299 Rattus norvegicus 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. C-1299 Homo sapiens 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
5-[[3-(dimethylamino)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADPH + H+ + O2 i.e. C-1305 Homo sapiens 5-[[3-(dimethylnitroryl)propyl]amino]-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one + NADP+ + H2O
-
 ?
additional information isozyme FMO5 does not metabolize 5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one (C-1305) Rattus norvegicus ?
-
 ?
additional information isozyme FMO5 does not metabolize C-1305 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase
-
 Rattus norvegicus
flavin-containing monooxygenase
-
 Homo sapiens
FMO1 isozyme Rattus norvegicus
FMO1 isozyme Homo sapiens
FMO5 isozyme Rattus norvegicus
FMO5 isozyme Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.4 8.4 the activity is approximately twice as high at pH 8.4 as at pH 7.4 Rattus norvegicus
7.4 8.4 the activity is approximately twice as high at pH 8.4 as at pH 7.4 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
FAD
-
 Homo sapiens
NADPH required for activity Rattus norvegicus
NADPH required for activity Homo sapiens

General Information

General Information Comment Organism
metabolism the flavin monooxygenase FMO1 contributes to metabolism of anti-tumor triazoloacridinone C-1305 (5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one) in liver microsomes Rattus norvegicus
metabolism the flavin monooxygenase FMO1 contributes to metabolism of anti-tumor triazoloacridinone, C-1305 (5-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one), in liver microsomes and Hep-G2 cells Homo sapiens