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Literature summary for 1.14.13.8 extracted from
- Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species (2010), J. Vet. Pharmacol. Ther., 33, 341-346.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Methimazole | - |
Bos taurus |  |
| Methimazole | - |
Oryctolagus cuniculus | |
| Methimazole | - |
Sus scrofa | |
| trimethylamine | - |
Bos taurus | |
| trimethylamine | - |
Oryctolagus cuniculus | |
| trimethylamine | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics, overview | Sus scrofa | |
| additional information | - |
additional information | Michaelis-Menten kinetics, overview | Bos taurus | |
| additional information | - |
additional information | Michaelis-Menten kinetics, overview | Oryctolagus cuniculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Bos taurus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzydamine + NADPH + H+ + O2 | Sus scrofa | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
| benzydamine + NADPH + H+ + O2 | Bos taurus | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
| benzydamine + NADPH + H+ + O2 | Oryctolagus cuniculus | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
| additional information | Sus scrofa | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? | |
| additional information | Bos taurus | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? | |
| additional information | Oryctolagus cuniculus | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
| brain | - |
Bos taurus | - |
| brain | - |
Oryctolagus cuniculus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzydamine + NADPH + H+ + O2 | - |
Sus scrofa | benzydamine N-oxide + NADP+ + H2O | - |
? | |
| benzydamine + NADPH + H+ + O2 | - |
Bos taurus | benzydamine N-oxide + NADP+ + H2O | - |
? | |
| benzydamine + NADPH + H+ + O2 | - |
Oryctolagus cuniculus | benzydamine N-oxide + NADP+ + H2O | - |
? | |
| additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Sus scrofa | ? | - |
? | |
| additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Bos taurus | ? | - |
? | |
| additional information | benzydamine is a weak base and an indazole derivative with analgesic and antipyretic properties used in human and veterinary medicine, it is metabolized to a wide range of metabolites. One of the main metabolites, benzydamine N-oxide is produced in the liver and brain by flavin-containing monooxygenases | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FMO | - |
Sus scrofa |
| FMO | - |
Bos taurus |
| FMO | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
| 37 | - |
assay at | Bos taurus |
| 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
| 7.4 | - |
assay at | Bos taurus |
| 7.4 | - |
assay at | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | - |
Sus scrofa | |
| flavin | - |
Bos taurus | |
| flavin | - |
Oryctolagus cuniculus | |
| NADPH | - |
Sus scrofa | |
| NADPH | - |
Bos taurus | |
| NADPH | - |
Oryctolagus cuniculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics, overview | Sus scrofa | |
| additional information | - |
additional information | inhibition kinetics, overview | Bos taurus | |
| additional information | - |
additional information | inhibition kinetics, overview | Oryctolagus cuniculus |
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