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Literature summary for 1.14.13.8 extracted from

  • Mitchell, S.
    Flavin mono-oxygenase (FMO) - The other oxidase (2008), Curr. Drug Metab., 9, 280-284.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
five genes encoding isozymes FMO1-FMO5 and 1 pseudogene organized in a gene cluster Homo sapiens

Protein Variants

Protein Variants Comment Organism
down FMO5 is downregulated in type II diabetes in liver. FMO1 downregulation and inhibition by 3,3'-diindolylmethane Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,3'-diindolylmethane competitive inhibition of FMO3 Homo sapiens
indole-3-carbinol competitive inhibition of FMO3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Sus scrofa
-
-
microsome
-
Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is regulated by hormones, e.g. testosterone ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from liver microsomes Sus scrofa
native enzyme from lung microsomes Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Sus scrofa
-
liver FMO1 is the major isozyme in liver Homo sapiens
-
liver FMO1 is the major isozyme in liver Rattus norvegicus
-
lung
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methimazole + NADPH + H+ + O2 N-oxidation Homo sapiens methimazole N-oxide + NADP+ + H2O
-
?
additional information the enzyme is regulated by hormones, e.g. testosterone Homo sapiens ?
-
?
thiobenzamide + NADPH + H+ + O2 N-oxidation Homo sapiens thiobenzamide N-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
flavin mono-oxygenase
-
Mus musculus
flavin mono-oxygenase
-
Homo sapiens
flavin mono-oxygenase
-
Rattus norvegicus
flavin mono-oxygenase
-
Sus scrofa
flavin mono-oxygenase
-
Oryctolagus cuniculus
FMO
-
Mus musculus
FMO
-
Homo sapiens
FMO
-
Rattus norvegicus
FMO
-
Sus scrofa
FMO
-
Oryctolagus cuniculus
FMO1
-
Mus musculus
FMO1
-
Homo sapiens
FMO1
-
Rattus norvegicus
FMO1
-
Sus scrofa
FMO1
-
Oryctolagus cuniculus
FMO2
-
Mus musculus
FMO2
-
Homo sapiens
FMO2
-
Rattus norvegicus
FMO2
-
Sus scrofa
FMO2
-
Oryctolagus cuniculus
FMO3
-
Mus musculus
FMO3
-
Homo sapiens
FMO3
-
Rattus norvegicus
FMO3
-
Sus scrofa
FMO3
-
Oryctolagus cuniculus
FMO4
-
Mus musculus
FMO4
-
Homo sapiens
FMO4
-
Rattus norvegicus
FMO4
-
Sus scrofa
FMO4
-
Oryctolagus cuniculus
FMO5
-
Mus musculus
FMO5
-
Homo sapiens
FMO5
-
Rattus norvegicus
FMO5
-
Sus scrofa
FMO5
-
Oryctolagus cuniculus

Expression

Organism Comment Expression
Rattus norvegicus bacterial lipopolysaccharides lead to enzyme downregulation in the liver, as well as posttranslationally S-nitrosylation by nitric oxide down
Oryctolagus cuniculus downregulation of FMO1 and FMO3 by glucocorticoids and progesterone down
Mus musculus in female mice, testosterone plays a role in negative FMO regulation down
Mus musculus liver FMO1 is upregulated in diabetic mice up
Rattus norvegicus liver FMO1 is upregulated in diabetic rats up