Cloned (Comment) | Organism |
---|---|
five genes encoding isozymes FMO1-FMO5 and 1 pseudogene organized in a gene cluster | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
down | FMO5 is downregulated in type II diabetes in liver. FMO1 downregulation and inhibition by 3,3'-diindolylmethane | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3'-diindolylmethane | competitive inhibition of FMO3 | Homo sapiens | |
indole-3-carbinol | competitive inhibition of FMO3 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is regulated by hormones, e.g. testosterone | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from liver microsomes | Sus scrofa |
native enzyme from lung microsomes | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Sus scrofa | - |
liver | FMO1 is the major isozyme in liver | Homo sapiens | - |
liver | FMO1 is the major isozyme in liver | Rattus norvegicus | - |
lung | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methimazole + NADPH + H+ + O2 | N-oxidation | Homo sapiens | methimazole N-oxide + NADP+ + H2O | - |
? | |
additional information | the enzyme is regulated by hormones, e.g. testosterone | Homo sapiens | ? | - |
? | |
thiobenzamide + NADPH + H+ + O2 | N-oxidation | Homo sapiens | thiobenzamide N-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin mono-oxygenase | - |
Mus musculus |
flavin mono-oxygenase | - |
Homo sapiens |
flavin mono-oxygenase | - |
Rattus norvegicus |
flavin mono-oxygenase | - |
Sus scrofa |
flavin mono-oxygenase | - |
Oryctolagus cuniculus |
FMO | - |
Mus musculus |
FMO | - |
Homo sapiens |
FMO | - |
Rattus norvegicus |
FMO | - |
Sus scrofa |
FMO | - |
Oryctolagus cuniculus |
FMO1 | - |
Mus musculus |
FMO1 | - |
Homo sapiens |
FMO1 | - |
Rattus norvegicus |
FMO1 | - |
Sus scrofa |
FMO1 | - |
Oryctolagus cuniculus |
FMO2 | - |
Mus musculus |
FMO2 | - |
Homo sapiens |
FMO2 | - |
Rattus norvegicus |
FMO2 | - |
Sus scrofa |
FMO2 | - |
Oryctolagus cuniculus |
FMO3 | - |
Mus musculus |
FMO3 | - |
Homo sapiens |
FMO3 | - |
Rattus norvegicus |
FMO3 | - |
Sus scrofa |
FMO3 | - |
Oryctolagus cuniculus |
FMO4 | - |
Mus musculus |
FMO4 | - |
Homo sapiens |
FMO4 | - |
Rattus norvegicus |
FMO4 | - |
Sus scrofa |
FMO4 | - |
Oryctolagus cuniculus |
FMO5 | - |
Mus musculus |
FMO5 | - |
Homo sapiens |
FMO5 | - |
Rattus norvegicus |
FMO5 | - |
Sus scrofa |
FMO5 | - |
Oryctolagus cuniculus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | bacterial lipopolysaccharides lead to enzyme downregulation in the liver, as well as posttranslationally S-nitrosylation by nitric oxide | down |
Oryctolagus cuniculus | downregulation of FMO1 and FMO3 by glucocorticoids and progesterone | down |
Mus musculus | in female mice, testosterone plays a role in negative FMO regulation | down |
Mus musculus | liver FMO1 is upregulated in diabetic mice | up |
Rattus norvegicus | liver FMO1 is upregulated in diabetic rats | up |