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Literature summary for 1.14.13.8 extracted from

  • Wu, R.F.; Ichikawa, Y.
    An essential lysyl residue (Lys208) in the substrate-binding site of porcine FAD-containing monooxygenase (1995), Eur. J. Biochem., 229, 749-753.
    View publication on PubMed
Search for more literature for 1.14.13.8

Inhibitors

Inhibitors Comment Organism Structure
Deprenyl strong, oxidative activity toward 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP Sus scrofa
Pargyline strong, oxidative activity toward 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 Pargyline
-
 Sus scrofa
0.014
-
 Deprenyl
-
 Sus scrofa
0.038
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2
-
 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + O2
-
 Sus scrofa ?
-
 ?
deprenyl + NADPH + H+ + O2
-
 Sus scrofa ?
-
 ?
pargyline + NADPH + O2 inhibitor of monoaminoxidase B Sus scrofa ?
-
 ?
R(-)-deprenyl + NADPH + O2 inhibitor of monoaminoxidase B Sus scrofa ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.009
-
 Pargyline oxidative activity toward 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP Sus scrofa
0.014
-
 Deprenyl oxidative activity toward 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP Sus scrofa