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Literature summary for 1.14.13.8 extracted from
- Hepatic microsomal mixed-function amine oxidase (1978), Methods Enzymol., 52, 142-151.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Guanidines | stimulate NADPH- and O2-dependent oxidation of tertiary amines and sulfur-containing substrates with alkyl side-chains of less than 5 carbons | Sus scrofa | |
| Lipophilic primary alkylamines | stimulate NADPH- and O2-dependent oxidation of tertiary amines and sulfur-containing substrates with alkyl side-chain of less than 5 carbons | Sus scrofa | |
| n-octylamine | stimulation of tert-amine oxidation, not sec-amine oxidation | Sus scrofa |  |
| tertiary amines | self-activation with alkyl side chains of 7 or more | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anionic detergents | - |
Sus scrofa | |
| fatty acids | - |
Sus scrofa | |
| SDS | - |
Sus scrofa | |
| stearate | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
8 * 65000, SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.43 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, several months with little or no loss of activity | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methimazole + NADPH + O2 | - |
Sus scrofa | N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O | - |
? | |
| additional information | catalyzes NADPH- and O2-dependent N-oxidation of N-substituted amines and hydrazines and the S-oxidation of thioureylenes and thiols | Sus scrofa | ? | - |
? | |
| N,N-dimethylaniline + NADPH + O2 | - |
Sus scrofa | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| octamer | 8 * 65000, SDS-PAGE | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | flavoprotein | Sus scrofa | |
| NADH | - |
Sus scrofa | |
| NADPH | - |
Sus scrofa | |
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Release 2023.1 (January 2023)
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