BRENDA - Enzyme Database
show all sequences of 1.14.13.70

Synthesis and molecular docking study of some new 1,4-phenylene-bisthiazoles as fungal lanosterol 14alpha-demethylase inhibitors

Borcea, A.; Marc, G.; Pirnau, A.; Vlase, L.; Ionut, I.; Tiperciuc, B.; Oniga, O.; Farmacia 65, 683-689 (2017)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
1-(4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-5-yl)ethanone
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-hydroxy-5-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)benzamide
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-methyl-4-(4-(4-(naphthalen-1-yl)thiazol-2-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-methyl-4-(4-(4-phenylthiazol-2-yl)phenyl)thiazole
the compounds is predicted to be a non-competitive inhibitors of the enzyme by molecular docking study
Candida albicans SC5314
4-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)-benzonitrile
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(4-chlorophenyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(4-methoxyphenyl)-2-(4-(2-methylthiazol-4-yl)-phenyl)thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(chloromethyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
ethyl 2-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)acetate
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
ethyl 4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole-5-carboxylate
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
Organism
Organism
UniProt
Commentary
Textmining
Candida albicans SC5314
P10613
-
-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-(4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-5-yl)ethanone
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-hydroxy-5-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)benzamide
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-methyl-4-(4-(4-(naphthalen-1-yl)thiazol-2-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
2-methyl-4-(4-(4-phenylthiazol-2-yl)phenyl)thiazole
the compounds is predicted to be a non-competitive inhibitors of the enzyme by molecular docking study
Candida albicans SC5314
4-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)-benzonitrile
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(4-chlorophenyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(4-methoxyphenyl)-2-(4-(2-methylthiazol-4-yl)-phenyl)thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
4-(chloromethyl)-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
ethyl 2-(2-(4-(2-methylthiazol-4-yl)phenyl)thiazol-4-yl)acetate
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
ethyl 4-methyl-2-(4-(2-methylthiazol-4-yl)phenyl)-thiazole-5-carboxylate
the compounds is predicted to be a non-competitive inhibitor of the enzyme by molecular docking study
Candida albicans SC5314
Other publictions for EC 1.14.13.70
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Synthesis and molecular docki ...
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