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Literature summary for 1.14.13.7 extracted from

  • Kim, J.Y.; Kim, J.K.; Lee, S.O.; Kim, C.K.; Lee, K.
    Multicomponent phenol hydroxylase-catalysed formation of hydroxyindoles and dyestuffs from indole and its derivatives (2005), Lett. Appl. Microbiol., 41, 163-168.
    View publication on PubMed

Application

Application Comment Organism
synthesis the multicomponent phenol hydroxylases can be used as biocatalysts for producing dyes, e.g. indigo, and hydroxyindoles such as 7-hydroxyindole from indole and its derivatives, overview, multicomponent phenol hydroxylases may serve as potential agents for organic syntheses as well as bioremediation Pseudomonas sp.

Cloned(Commentary)

Cloned (Comment) Organism
expression of enzyme from strain KL33 and KL28 in Escherichia coli Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas sp. phenol degradation pathway, overview ?
-
?
phenol + NADPH + O2 Pseudomonas sp.
-
catechol + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
strains KL28 and KL33
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information strain KL28 is a strain that can grow on n-alkylphenols as a carbon and energy source Pseudomonas sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
3-cyanoindole + NADPH + O2 substrate only of strain KL28 Pseudomonas sp. ?
-
?
4-hydroxyindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
4-methoxyindole + NADPH + O2 substrate only of strain KL28 Pseudomonas sp. ?
-
?
4-methylindole + NADPH + O2 substrate only of strain KL28 Pseudomonas sp. ?
-
?
5-aminoindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
5-fluoroindole + NADPH + O2 substrate only of strain KL33 Pseudomonas sp. ?
-
?
5-hydroxyindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
5-methoxyindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
5-methylindole + NADPH + O2 substrate only of strain KL33 Pseudomonas sp. ?
-
?
6-chloroindole + NADPH + O2 substrate only of strain KL33 Pseudomonas sp. ?
-
?
6-methoxyindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
6-methylindole + NADPH + O2 substrate only of strain KL33 Pseudomonas sp. ?
-
?
7-chloroindole + NADPH + O2 substrate only of strain KL33 Pseudomonas sp. ?
-
?
7-methylindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
indole + NADPH + O2
-
Pseudomonas sp. 7-hydroxyindole + NADP+ + H2O
-
?
additional information phenol degradation pathway, overview Pseudomonas sp. ?
-
?
additional information the enzyme is a multicomponent phenol hydroxylase, production of dyes from indole derivatives by recombinant enzymes expressed in Escherichia coli, substrate specificities of the enzyme from strain KL28 and KL33, the products formed by the enzyme from the two strain are different, detailed overview Pseudomonas sp. ?
-
?
oxindole + NADPH + O2
-
Pseudomonas sp. ?
-
?
phenol + NADPH + O2
-
Pseudomonas sp. catechol + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
multicomponent phenol hydroxylase
-
Pseudomonas sp.

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Pseudomonas sp.