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Literature summary for 1.14.13.39 extracted from

  • Aquilano, K.; Baldelli, S.; Rotilio, G.; Ciriolo, M.R.
    Role of nitric oxide synthases in Parkinsons disease: a review on the antioxidant and anti-inflammatory activity of polyphenols (2008), Neurochem. Res., 33, 2416-2426.
    View publication on PubMed
Search for more literature for 1.14.13.39

Cloned(Commentary)

Cloned (Comment) Organism
expressed in SH-SY5Y cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the raise of intracellular calcium levels increases nNOS dephosphorylation and enzymatic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P29475
-
-
Homo sapiens P35228
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
microglial cell line
-
 Homo sapiens
-
substantia nigra
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Homo sapiens 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?

Synonyms

Synonyms Comment Organism
inducible NO synthase
-
 Homo sapiens
iNOS
-
 Homo sapiens
mitochondrial NO synthase
-
 Homo sapiens
mtNOS
-
 Homo sapiens
neuronal NO synthase
-
 Homo sapiens
nNOS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens up-regulation of the inflammatory gene encoding for iNOS is observed in a population of amoeboid microglial cells from Parkinson's disease patients, iNOS up-regulation in microglia seems to play an important role in the onset of inflammatory processes in Parkinsons's disease and acts synergistically with other inflammatory mediators, Parkinsons's disease-inducing drugs such as rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or dopamine overexposure provoke activation of iNOS expression up