Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NG-Nitro-L-arginine | complete inhibition at 1 mM, non-selective NOS inhibitor; complete inhibition at 1 mM, non-selective NOS inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
membrane | total NOS activity is enriched in the intracellular membrane fraction at normal salt diet | Rattus norvegicus | 16020 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P29476 | - |
- |
Rattus norvegicus | Q62600 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
renal inner medulla | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Rattus norvegicus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NOS1 | isozyme | Rattus norvegicus |
NOS3 | isozyme | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | 0.003 mM | Rattus norvegicus | |
Calmodulin | 30 nM | Rattus norvegicus | |
NADPH | 1 mM | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | expression of isozyme NOS1 protein is decreased in the cytoplasmic and plasma membrane fractions, although maintained in the intracellular membrane fraction, in response to high salt | down |
Rattus norvegicus | expression of isozyme NOS3 protein is unaffected by high salt | additional information |