Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.39 extracted from

  • Sullivan, J.; Smart, E.; Pollock, D.; Pollock, J.
    Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla (2008), Clin. Exp. Pharmacol. Physiol., 35, 120-125.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NG-Nitro-L-arginine complete inhibition at 1 mM, non-selective NOS inhibitor; complete inhibition at 1 mM, non-selective NOS inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
membrane total NOS activity is enriched in the intracellular membrane fraction at normal salt diet Rattus norvegicus 16020
-
plasma membrane
-
Rattus norvegicus 5886
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476
-
-
Rattus norvegicus Q62600
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
renal inner medulla
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
Rattus norvegicus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
NOS1 isozyme Rattus norvegicus
NOS3 isozyme Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin 0.003 mM Rattus norvegicus
Calmodulin 30 nM Rattus norvegicus
NADPH 1 mM Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus expression of isozyme NOS1 protein is decreased in the cytoplasmic and plasma membrane fractions, although maintained in the intracellular membrane fraction, in response to high salt down
Rattus norvegicus expression of isozyme NOS3 protein is unaffected by high salt additional information