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Literature summary for 1.14.13.39 extracted from

  • Lee, Y.Z.; Yang, C.W.; Kang, I.J.; Wu, S.H.; Chao, Y.S.; Chern, J.H.; Lee, S.J.
    Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma (2008), Bioorg. Med. Chem. Lett., 18, 5676-5679.
    View publication on PubMed
Search for more literature for 1.14.13.39

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
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 Mus musculus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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 ?

Synonyms

Synonyms Comment Organism
inducible nitric oxide synthase
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 Mus musculus
iNOS
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 Mus musculus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
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 Mus musculus
Calmodulin
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 Mus musculus
NADPH
-
 Mus musculus

Expression

Organism Comment Expression
Rattus norvegicus 0.01 mM 2-phenyl-ethenesulfonic acid phenyl ester, 2-phenyl-ethenesulfonic acid 4-chlorophenyl ester, and 2-methyl-4-nitro-quinoline 1-oxide inhibit the expression of inducible nitric oxide synthase protein, 4-nitro-quinoline 1-oxide reveals no significant expression-downregulating activity at 0.01 mM down