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Literature summary for 1.14.13.39 extracted from

  • Widdison, S.; Ashley, G.R.; Howard, C.J.; Coffey, T.J.
    Characterisation of bovine inducible nitric oxide synthase (2007), Vet. Immunol. Immunopathol., 117, 302-309.
    View publication on PubMed
Search for more literature for 1.14.13.39

Activating Compound

Activating Compound Comment Organism Structure
additional information iNOS is induced by pathogens and their components, e.g. induction in alveolar macropages by infection with the intracellular pathogen Mycobacterium bovis Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
iNOS, DNA and amino acid sequence determination and analysis, phylogenetic analysis Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 Bos taurus NO is an important signalling molecule, released by numerous cells, that acts in many tissues to regulate a diverse range of physiological and biological processes, including neurotransmission, immune defence and the regulation of apoptosis. NO plays a major role in the killing of intracellular pathogens as part of the innate immune response 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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Organism

Organism UniProt Comment Textmining
Bos taurus Q9BDQ7 fragment of iNOS
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage alveolar Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Bos taurus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 NO is an important signalling molecule, released by numerous cells, that acts in many tissues to regulate a diverse range of physiological and biological processes, including neurotransmission, immune defence and the regulation of apoptosis. NO plays a major role in the killing of intracellular pathogens as part of the innate immune response Bos taurus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?

Subunits

Subunits Comment Organism
More iNOS domain structure, overview Bos taurus

Synonyms

Synonyms Comment Organism
inducible nitric oxide synthase
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 Bos taurus
iNOS
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 Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD binding site sequence, overview Bos taurus
flavodoxin I binding site sequence, overview Bos taurus
NADPH binding site sequence, overview Bos taurus