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Literature summary for 1.14.13.39 extracted from

  • Wei, C.L.; Hon, W.M.; Lee, K.H.; Khoo, H.E.
    Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis (2005), World J. Gastroenterol., 11, 362-367.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.39

Activating Compound

Activating Compound Comment Organism Structure
additional information hepatic isozyme iNOS expression is induced in chronic liver cirrhosis early stages Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
additional information Rattus norvegicus NO is implicated in the pathogenesis of liver cirrhosis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q06518 male Sprague-Dawley rats, isozyme iNOS
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
liver temporal expression of hepatic iNOS in liver cirrhosis, induced in rats by chronic bile duct ligation, overview Rattus norvegicus
-
additional information expression analysis in isolated hepatocytes, healthy liver, and cirrhotic liver, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
additional information NO is implicated in the pathogenesis of liver cirrhosis, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
inducible nitric oxide synthase
-
 Rattus norvegicus
iNOS
-
 Rattus norvegicus
nitric oxide synthase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus