Literature summary for 1.14.13.39 extracted from

Lemaire, J.F.; McPherson, P.S.
Binding of Vac14 to neuronal nitric oxide synthase: characterisation of a new internal PDZ-recognition motif (2006), FEBS Lett., 580, 6948-6954.

Search for more literature for 1.14.13.39

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression of the enzyme and Vac14 as GST- or His-tagged proteins in Escherichia colis train BL21, expression of Vac14 as FLAG-tagged protein in HEK-293T cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme interacts with Vac14, the activator of the PtdIns(3)P 5-kinase PIKfyve, the beta-finger independent interaction is based on an internal motif, sequence -G-D-H-L-D-, for PDZ recognition, PDZ domains are protein interaction modules found in single or multiple copies in a variety of proteins involved in multiprotein signaling complexes, interaction study with wild-type and mutant Vac14 proteins, binding is not abolished by deletion of the last five amino acids, but is abolished with deletions of the last 53 or last 10 residues of Vac14, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
neuronal nitric oxide synthase	-	Homo sapiens
nNOS	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)